Journal of Yeungnam Medical Science

Daewon Jeong

2 Articles

Osteoimmunology: Daewon Jeong; Yeungnam Univ J Med. 2007;24(2 Suppl):S270-276. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S270

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Bone is the only solid organ and serves as a mechanical support and a reservoir of minerals. Bone homeostasis is achieved by the balance between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts, which are derived from mesenchymal stem cells, secrete bone matrix proteins and promote mineralization. Otherwise, osteoclasts are derived from hematopoietic stem cells (HSC) that are capable of differentiating into all immune cells and resorb bone matrix by acid decalcification and proteolytic degradation. Osteobalsts and osteoclasts are an important role in the regulation of HSC niche and development, showing that bone remodeling was linked to hematopoietic regulation. Long-lived memory T and B cells and bone cells coexist in the bone marrow reservoir as well as activated T cells that mediate adaptive immune system and osteoclasts that regulate bone turnover share a common molecules that are essential for their development and differentiation. In addition, activated T cell-expressed RANKL directly stimulates osteoclastogenesis. Accumulating evidence indicates that there is the interplay between the immune-related cells and bone remodeling-related cells. This review will discuss the osteoimmunology, an interdisciplinary approach to understanding the cross-talk between bone and the immune cells.

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The Study on the Korean and Western Medical Literatures for Aging and Skin Aging
Jung-Min Han, Woo-Shin Ko, Hwa-Jung Yoon
The Journal of Korean Oriental Medical Ophthalmology and Otolaryngology and Dermatology.2014; 27(1): 45. CrossRef

Selenium Metabolism: Daewon Jeong; Yeungnam Univ J Med. 2007;24(2 Suppl):S277-282. Published online December 31, 2007; DOI: https://doi.org/10.12701/yujm.2007.24.2S.S277

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Abstract PDF: Selenium is an essential biological trace element in mammals and adults should be intake 100 μg per day. Selenium is inserted into selenoproteins as selenocysteine (Sec), which is encoded by the UGA “STOP” codon in open reading frame. The translational process for selenoproteins in mammals is achieved by various components, such as the selenocysteineinsertion- sequence (SECIS) in the untranslated region of mRNA, the SECIS-binding protein SBP2, the Sec-specific translation factor EF-Sec, and the Sec-specific tRNASec. Generally, most selenoproteins including glutathione peroxidase and thioredoxin reductase exhibit antioxidant function to protect cells from oxidative stress. In addition, thyroxine deiodinase plays an important role in the control of thyroid hormone metabolism. These results indicate that the adequate diet of selenium is essential for maintaining redox status and hormone. On the other hand, a deficiency intake of selenium shows Keshan’s disease (cardiomyopathy), Kashin-Beck disease (osteoarthritis), white muscle disease, and cretinism as well as an excessive intake of selenium results in toxic symptoms, including blind staggers and alkaline diseases. Therefore, an adequate intake of selenium is necessary to maintain in vivo function. The aim of this review is to discuss the role of selenium in vivo.

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